您可以使用codecs模块，如下所示：

import codecs
BLOCKSIZE = 1048576 # or some other, desired size in bytes
with codecs.open(sourceFileName, "r", "your-source-encoding") as sourceFile:
    with codecs.open(targetFileName, "w", "utf-8") as targetFile:
        while True:
            contents = sourceFile.read(BLOCKSIZE)
            if not contents:
                break
            targetFile.write(contents)

编辑 ：添加BLOCKSIZE参数以控制文件块大小。