SFTP支持常用的FTP命令（chdir，mkdir等），因此请使用以下命令：

sftp = paramiko.SFTPClient.from_transport(transport)
try:
    sftp.chdir(remote_path)  # Test if remote_path exists
except IOError:
    sftp.mkdir(remote_path)  # Create remote_path
    sftp.chdir(remote_path)
sftp.put(local_path, '.')    # At this point, you are in remote_path in either case
sftp.close()

要完全仿真mkdir -p，您可以递归地遍历remote_path：

import os.path

def mkdir_p(sftp, remote_directory):
    """Change to this directory, recursively making new folders if needed.
    Returns True if any folders were created."""
    if remote_directory == '/':
        # absolute path so change directory to root
        sftp.chdir('/')
        return
    if remote_directory == '':
        # top-level relative directory must exist
        return
    try:
        sftp.chdir(remote_directory) # sub-directory exists
    except IOError:
        dirname, basename = os.path.split(remote_directory.rstrip('/'))
        mkdir_p(sftp, dirname) # make parent directories
        sftp.mkdir(basename) # sub-directory missing, so created it
        sftp.chdir(basename)
        return True

sftp = paramiko.SFTPClient.from_transport(transport)
mkdir_p(sftp, remote_path) 
sftp.put(local_path, '.')    # At this point, you are in remote_path
sftp.close()

当然，如果remote_path也包含一个远程文件名，则需要将其拆分，将目录传递给mkdir_p并使用文件名代替“。”。在sftp.put中。