我确实找到的一种解决方案依赖于ctypes从创建一个objc_object对象id：

import ctypes, objc
_objc = ctypes.PyDLL(objc._objc.__file__)

# PyObject *PyObjCObject_New(id objc_object, int flags, int retain)
_objc.PyObjCObject_New.restype = ctypes.py_object
_objc.PyObjCObject_New.argtypes = [ctypes.c_void_p, ctypes.c_int, ctypes.c_int]

def objc_object(id):
    return _objc.PyObjCObject_New(id, 0, 1)

用于打印的示例wx.Frame：

import wx

class Frame(wx.Frame):
    def __init__(self, title):
        wx.Frame.__init__(self, None, title=title, pos=(150,150), size=(350,200))

        m_print = wx.Button(self, label="Print")
        m_print.Bind(wx.EVT_BUTTON, self.OnPrint)

    def OnPrint(self, event):
        topobj = objc_object(top.GetHandle())
        topobj.print_(None)

app = wx.App()
top = Frame(title="ObjC Test")
top.Show()

app.MainLoop()

因为使用，所以有点讨厌ctypes。如果有pyobjc我忽略的API函数或其他更巧妙的方法，我肯定会感兴趣。