Moq版本4.8（或更高版本）对by-ref参数的支持大大改善：

public interface IGobbler
{
    bool Gobble(ref int amount);
}

delegate void GobbleCallback(ref int amount);     // needed for Callback
delegate bool GobbleReturns(ref int amount);      // needed for Returns

var mock = new Mock<IGobbler>();
mock.Setup(m => m.Gobble(ref It.Ref<int>.IsAny))  // match any value passed by-ref
    .Callback(new GobbleCallback((ref int amount) =>
     {
         if (amount > 0)
         {
             Console.WriteLine("Gobbling...");
             amount -= 1;
         }
     }))
    .Returns(new GobbleReturns((ref int amount) => amount > 0));

int a = 5;
bool gobbleSomeMore = true;
while (gobbleSomeMore)
{
    gobbleSomeMore = mock.Object.Gobble(ref a);
}

相同的模式适用于out参数。

It.Ref<T>.IsAny也适用于C＃7 in参数（因为它们也是by-ref）。