如果您使用的是Spring Boot，则以下设置可以为您提供帮助：

配置类：

@Configuration
public class DatasourceConfig {

    @Primary
    @Bean
    @ConfigurationProperties(prefix = "datasource.primary")
    public DataSource primaryDataSource() {
        return DataSourceBuilder.create().build();
    }

    @Bean
    @ConfigurationProperties(prefix = "datasource.primary.liquibase")
    public LiquibaseProperties primaryLiquibaseProperties() {
        return new LiquibaseProperties();
    }

    @Bean
    public SpringLiquibase primaryLiquibase() {
        return springLiquibase(primaryDataSource(), primaryLiquibaseProperties());
    }

    @Bean
    @ConfigurationProperties(prefix = "datasource.secondary")
    public DataSource secondaryDataSource() {
        return DataSourceBuilder.create().build();
    }

    @Bean
    @ConfigurationProperties(prefix = "datasource.secondary.liquibase")
    public LiquibaseProperties secondaryLiquibaseProperties() {
        return new LiquibaseProperties();
    }

    @Bean
    public SpringLiquibase secondaryLiquibase() {
        return springLiquibase(secondaryDataSource(), secondaryLiquibaseProperties());
    }

    private static SpringLiquibase springLiquibase(DataSource dataSource, LiquibaseProperties properties) {
        SpringLiquibase liquibase = new SpringLiquibase();
        liquibase.setDataSource(dataSource);
        liquibase.setChangeLog(properties.getChangeLog());
        liquibase.setContexts(properties.getContexts());
        liquibase.setDefaultSchema(properties.getDefaultSchema());
        liquibase.setDropFirst(properties.isDropFirst());
        liquibase.setShouldRun(properties.isEnabled());
        liquibase.setLabels(properties.getLabels());
        liquibase.setChangeLogParameters(properties.getParameters());
        liquibase.setRollbackFile(properties.getRollbackFile());
        return liquibase;
    }


...

}

properties.yml

datasource:
  primary:
    url: jdbc:mysql://localhost/primary
    username: username
    password: password
    liquibase:
      change-log: classpath:/db/changelog/db.primary.changelog-master.xml
  secondary:
    url: jdbc:mysql://localhost/secondary
    username: username
    password: password
    liquibase:
      change-log: classpath:/db/changelog/db.secondary.changelog-master.xml